Molecular, Biological and Content Studies on Colchicum L. Species
Keywords:
Colchicum, Phylogenetic, Phytochemical, Biological ActivityAbstract
Colchicaceae family of the genus Colchicum L. is in the 39 taxa present in Turkey which 18 are endemic. The Colchicine compound found in Colchicum species was obtained in the past, but its structure was not fully found. In the following years, this substance was developed further and reached today and was used in the treatment of diseases such as gout, rheumatism, asthma and dysentery. These species were investigated in terms of phylogenetic analysis, phytochemical content and biological activities. In many phytochemical studies, there are studies in which colchicine and its derivative compounds, which are alkaloids, have been isolated. Many antioxidant and total secondary metabolite quantification experiments such as DPPH free radical scavenging activity, metal chelation, FRAP, CUPRAC, determination of total phenolic assays were carried out on different solvent extracts of Colchicum species. In studies using extracts of these species, some observed that it has antioxidant enzyme inhibitory activity. The antimicrobial activities of the extracts tested on different bacterial strains have been reported. Apart from these studies, different cell lines were used on different strains of this species and their cytotoxic results were compared. The effects of colchicine obtained from Colchicum species on various diseases were investigated. In this review, detailed information is given about phylogenetic analysis, phytochemical, pharmacological and biological activity (antioxidant, antioxidant enzyme inhibitor, anti-inflammatory, antimicrobial, cytotoxic) studies.
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